Two pathways of costimulation through CD28
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چکیده
منابع مشابه
SnapShot: B7/CD28 Costimulation
B7-1 (CD80) Inducible: APCs (slower kinetics than B7-2), T cells CD28 Constitutive: mouse (all T cells), human (95% of CD4+, 50% of CD8+ T cells), plasma cells, NK cells Stimulation of naive and previously activated T cells upon TCR ligation: ↑ proliferation (↓ p27Kip1, ↑ G1/S); ↑ cytokine production (↑ NFκB, ↑ IL2); ↑ survival (↑ Bcl-xL, ↑ survival of Tregs); ↑ glucose metabolism; provides T c...
متن کاملMemory CD8+ T cells require CD28 costimulation.
CD8(+) T cells are a critical component of the adaptive immune response against infections and tumors. A current paradigm in immunology is that naive CD8(+) T cells require CD28 costimulation, whereas memory CD8(+) T cells do not. We show here, however, that during viral infections of mice, costimulation is required in vivo for the reactivation of memory CD8(+) T cells. In the absence of CD28 c...
متن کاملCostimulation of IL-2 Production through CD28 Is Dependent on the Size of Its Ligand
Optimal T cell activation typically requires engagement of both the TCR and costimulatory receptors, such as CD28. Engagement of CD28 leads to tyrosine phosphorylation of its cytoplasmic region and recruitment of cytoplasmic signaling proteins. Although the exact mechanism of CD28 signal transduction is unknown, CD28 triggering has similarities to the TCR, which was proposed to use the kinetic-...
متن کاملStrong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling.
CD28 costimulation is required for the generation of naturally derived regulatory T cells (nTregs) in the thymus through lymphocyte-specific protein tyrosine kinase (Lck) signaling. However, it is not clear how CD28 costimulation regulates the generation of induced Tregs (iTregs) from naive CD4 T-cell precursors in the periphery. To address this question, we induced iTregs (CD25(+)Foxp3(+)) fro...
متن کاملIMMUNOBIOLOGY Strong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signaling
CD28 costimulation is required for the generation of naturally derived regulatory T cells (nTregs) in the thymus through lymphocyte-specific protein tyrosine kinase (Lck) signaling. However, it is not clear how CD28 costimulation regulates the generation of induced Tregs (iTregs) from naive CD4 T-cell precursors in the periphery. To address this question, we induced iTregs (CD25 Foxp3 ) from na...
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ژورنال
عنوان ژورنال: Immunologic Research
سال: 2009
ISSN: 0257-277X,1559-0755
DOI: 10.1007/s12026-009-8097-6